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Erectile Dysfunction

Erection problems (impotence) are very common, particularly in men over 40.

Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.

If it happens more often, it may be caused by physical or emotional problems.

Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.

Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety

Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week

  • Side Effects

    Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

    If you experience any of the following side effects stop using the medicine and seek medical help immediately:

    allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:

    Common (seen in 1 to 10 in every 100 patients)

    headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)

    dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)

    fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.

    Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

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    fortablefortableuphweight, can be taken with most medicines

  • Drug Interactions

    Cialis can interact with other medications. This is why you should not take Cialis with other medications being taken for high blood pressure or liver disease:

    Cialis can lower blood pressure, so it can also lower blood pressure-lowering medications like disulfiram (Antfa-zid) and isosorbide mononitrate (Imdur). Anttypes of organ transplant medication may also affect blood blood pressure.

    Cialis can lower blood pressure-lowering medications like disulfiram (Antfa-zid) and isosorbide mononitrate (Imdur). Anttypes of organ transplant medication may affect blood blood pressure. It is therefore not possible to determine whether Cialis will or will not lower blood pressure-lowering medications.

    Cialis can also affect the effects of nitrates in some drugs. Do not use Cialis with nitrates-based medications, because this may result in a sudden and severe drop in blood pressure (a dangerous fall in blood pressure-blooded drug).

    Do not take Cialis with alpha-blockers, particularly used at the start of angina medications. These can worsen blood pressure and can be fatal.

  • Before starting Cialis, read the Patient Information Leaflet (PIL) and ask your doctor or pharmacist to explain any other medications or supplements you are taking. Cialis may be taken with or without food.

    Erectile dysfunction (ED) can affect a man's ability to get or maintain an erection during sexual activity. It may be caused by a combination of factors, including hormonal imbalances, psychological issues, and medical conditions. To find out if you have ED, talk to your doctor or pharmacist.

    If you're dealing with ED and you have underlying health conditions that could be causing it, such as diabetes or high blood pressure, your doctor may request certain tests to rule out other conditions. These tests may include a blood test to check for prostate cancer, a urine test to measure urine flow, or a test to see how well your blood works. Some tests may also be used to treat or prevent conditions that could be causing ED.

    Before starting Cialis, tell your doctor and pharmacist if you are taking any other medications, including other drugs that treat ED. Cialis may affect these medications if taken with certain other medications. Tell your doctor and pharmacist if you are taking any of the following medications: nitrates (such as isosorbide dinitrate, isosorbide mononitrate, and nitroglycerin), alpha-blockers (such as beclomethasone, Dolophine), other phosphodiesterase 5 (PDE5) inhibitors (such as tamsulosin, Yes, and mizog defund tadalafil), other medications for erectile dysfunction (such as sildenafil, tamsulosin, and vardenafil), or alpha-blockers used to treat benign prostatic hyperplasia (BPH).

    Erectile dysfunction may be a symptom of other conditions that affect your body, such as diabetes, high blood pressure, or high cholesterol. Tell your doctor if you are taking any other medications, including other drugs that treat ED.

    Erectile dysfunction can have several causes, including physical, psychological, and a combination of factors. Tell your doctor if you have heart disease, high blood pressure, low blood pressure, diabetes, or are over 65, or have had a heart attack, heart surgery, or prostate cancer.

    Erectile dysfunction may be a sign of a more serious condition, such as benign prostatic hyperplasia (BPH), an enlarged prostate, or acute urinary retention. Your doctor should do a physical exam if you experience difficulty urinating or if you have a bowel movement that does not stop; your doctor may need to change your dose or frequency of intercourse to try and get an erection; or urinate more often than usual or you might need to have sexual activity for longer than usual.

    Your doctor may adjust your dose of Cialis if you have any of these conditions: high blood pressure; low blood pressure; uncontrolled high blood pressure; a history of stroke or heart attack; a tumor in your prostate; or a bleeding or blood-related disorder (such as haemophilia).

    If you experience any of the following symptoms, call your doctor: low blood pressure, feeling dizzy, blurred vision, difficulty breathing, swelling of the legs or feet, fever, swollen lymph glands, and a red or swollen spot on your skin.

    Tell your doctor or pharmacist, if you have any of the following conditions: breast cancer, prostate cancer, bowel problems, gallbladder disease, diabetes, heart problems, or uncontrolled high blood pressure.

    Interactions

    A. Top Drug-Drug Interactions:

    1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

    2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

    3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

    Other Drug-Drug interactions:

    • Ketoconazole, itraconazole (used to manage fungal infection)
    • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
    • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
    • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
    • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

    B. Drug-Food Interactions:

    Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

    1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
    2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
    3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
    4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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    Here are the key drug-food Interactions to be aware of:

    1. Grapefruit and Grape Juice: Grapefruit can increase the levels of tadalafil by inhibiting an enzyme called 5-alpha reductase. This enzyme is responsible for converting testosterone into estrogen and testosterone.
    2. : Though not a direct interaction, combining Cialis with grapefruit juice might worsen side effects like headaches or increase tadalafil availability in sensitive individuals.
    3. : While taking Cialis, individuals with an intolerant type of food may find them lighter than sensitive, particularly when taken with grapefruit or grapefruit juice. Avoid consuming these foods while using Cialis.

    Cialis

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    Cialis 2.5mg

    Cialis 2.5mg tablets treat erectile dysfunction (impotence) in men. Each tablet contains 20mg tadalafil and 20mg sildenafil. Cialis works by allowing for increased blood flow to the penis, helping to achieve and maintain an erection.

    Tadalafil

    Tadalafil is a phosphodiesterase-5 (PDE-5) inhibitor. It works by relaxing the blood vessels in your penis, allowing blood to flow into your penis when you get sexually excited (e.g. driving).

    How It Works

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    Cialis contains the active ingredient tadalafil.

    Tadalafil belongs to a class of medications called phosphodiesterase-5 inhibitors. when you're looking for a hard time whether you're having a romantic moment or ejaculating).

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